Bioengineered skin consists of an outer epidermal layer and/or a dermal layer (the layer of skin between the epidermis and the subcutaneous tissue) implanted into an acellular matrix (a support structure) forming a biological skin substitute. This ‘artificial’ tissue can be developed from the patient's own cells or from another ‘allogeneic‘ (non-self) source. Most commercial bioengineered skin comprises sheets of cells obtained from the neonatal (allogenic) foreskin.
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