Tissue engineering developed the therapeutic potential for wound healing and for wounds that are not open to primary closure. Over the past years, there have been remarkable advances in our understanding of the molecular and cellular processes involved in acute wound healing and in the pathobiology of chronic wounds. Improved knowledge has led to wound care advances. There are there important areas of research involved in stimulating complex wounds to heal by using biologics (growth factors and stem cells), use of artificial extracellular matrices for regeneration, effect of mechanical forces on wound healing. Four components are essential for tissue engineering. Stem cells, a matrix or scaffold, a bioreactor (culture medium), cytokines. The two major approaches have been utilized to develop engineered tissue includes In vitro (cellular constructs) and In vivo (acellular constructs). The goal of tissue engineering has been initially to substitute in patients with extensive burns wounds with tissue engineered autologous materials.
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