Stem cells are well well-known for its characterized and property of self-renewal and differentiate as multipotency cells., Stem Cells can act as a most therapeutic potential and attractive option for the treatment of chronic wounds, due to its ability to secrete proregenerative cytokines. The connective tissue that is characterized within the skin by disorganized collagen structure, loss of hair follicles and irregular vascular structure is often used in the replacement of wounded tissues in adults. But, the traditional tissue with the activity of stem cells is preferred to replace in the case of wounded fetal tissue. An achievable technique for tissue regeneration in adults is to seed adult somatic cell within a tissue bed "soil" in a wound bed and allow the stem cells to promote differentiation within the tissue bed cells. This technique produces a regenerative response additional almost like fetal wound healing than adult connective tissue formation. Even now scientists are investigating for totally different aspects of the "soil" tissue that is conducive to regeneration.